Long-chain fatty acid oxidation disorders (LC-FAODs) are a group of rare genetic conditions that prevent the body from breaking down stored fat into fatty acids and then into energy. Normally, proteins called enzymes assist in breaking down these fatty acid chains. People with these conditions have a missing or defective enzyme; therefore, they are unable to break down fatty acids into energy. The breakdown of fatty acids is necessary for energy production when sugar, or glucose, levels are low, and the body is not taking in enough food or requires more calories than usual. When the body can’t convert fat into energy as it should, this can lead to severe depletion of glucose in the body and a build up of fatty acid levels in the heart, liver, and skeletal muscle. As a result, patients can experience complications based on the organs involved such as low blood sugar, muscle pain or weakness, or an acute metabolic crisis.