JYNARQUE® is part of a Risk Evaluation and Mitigation Strategy, or REMS, program to ensure that you are closely monitored for signs of liver injury. The best way to monitor your liver health is by having your blood tested for any elevated levels of certain liver enzymes. The risk of liver injury is greatest at the start of therapy and reduces over time, but it can occur anytime during treatment.³ Therefore, you need to receive blood tests more frequently at the start of treatment and less frequently later.